Available SoonEleni Kaldoudi, Democritus University of ThraceA Spectroscopic Journey from Beer-Lambert to CAR-T Cell ProductionBruno Wacogne, FEMTO-ST, UMR CNRS 6174, FranceAvailable SoonWilliam Marnane, University College Cork, Ireland
Short Bio Eleni Kaldoudi received a PhD in Bioengineering from UCL, London, UK (1994). Currently, she is a Professor in Medical Physics - Medical Informatics at the School of Medicine, Democritus University of Thrace, Greece and an Adjunct Researcher in ATHENA Research Center for Information and Communication Technologies, Greece. Her research interests are within the areas of medical informatics and telematics, in which she has published one book and over 100 papers in various journals and conference proceedings. She is currently coordinating the Horizon Europe 9.5MEuro project ThrombUS+ towards a novel approach and device for wearable continuous point-of-care monitoring, risk estimation and prevention for deep vein thrombosis. Eleni is also acting as the President of the European Alliance for Medical and Biological Engineering and Science (EAMBES).
Abstract Available Soon
Short Bio Dr Bruno Wacogne is a CNRS Research Director at the FEMTO-ST Institute (one of the biggest Science and Technologies laboratory in France) where he was the head of the "Photonics for medical instrumentation" team before to join the BioMicroDevices group. He works now in the BIND group. He created and has led the Biom'@x transversal axis "Science et technology for personalized medicine" within this Institute for 15 years. In 2010, at the request of Besançon University Hospital, he applied and has been awarded a Translational Research Fellow position from the National AVIESAN Alliance. This is a supplementary position that allows him to be at the interface between the health activities at the FEMTO-ST Institute and the Clinical Investigation Center in Technological Innovation at Besançon University Hospital. At the hospital, he is the vice-coordinator of the Technological Innovation unit. His research interests concern translational research, science and technology for health and more precisely immuno-combined medical devices, biological qualification devices and biomedical optics. He now focuses on automated CAR-T cells culture systems. He is the author or co-author of over 250 communications among which about 40 invited conferences and keynote lectures and 10 patents. He is regularly chairman in international conferences. He has been awarded several times: Gold Micron at the International MICRONORA Workshop in 2006, Best Poster Award at the 2nd International Conference on Bio-sensing Technology in 2011, and Best Paper Award at the 13th International Conference on Biomedical Electronics and Devices in 2020. His research interests concern translational research, science and technology for health and more precisely immuno-combined medical devices, biological qualification devices and biomedical optics. He author or co-author of over 230 communications among which about 30 invited conferences. He is regularly chairman in international conferences. He has been awarded several times: Gold Micron at the International MICRONORA Workshop in 2006, Best Poster Award at the 2nd International Conference on Bio-sensing Technology in 2011, and Best Paper Award at the 13th International Conference on Biomedical Electronics and Devices in 2020.
Abstract CAR-T cell therapies represent a breakthrough in cancer treatment, yet their widespread adoption is hindered by high production costs. Currently, essential quality control methods, performed throughout the production process, rely on bioreactor sampling—a process that paradoxically introduces additional contamination risks. To overcome these challenges, quality control must be re-imagined: real-time, label-free and closed-system monitoring that eliminates sampling and enables immediate intervention at the first sign of culture degradation. White light spectroscopy emerges as a transformative solution. Leveraging recent advancements in ultra-miniaturized spectrometers and embedded signal processing, this approach can deliver precise, label-free and sampling-less monitoring without the need for complex infrastructure. In this keynote, we will share recent results of real-time T-cell concentration and viability assessment, as well as contamination and cell death detection. Most significantly, and to our knowledge, we will introduce the first proof of concept of a fully automated culture system capable of real-time, sampling-less, and label-free monitoring—a milestone in the quest for safer, more cost-effective CAR-T cell production.
Short Bio William Marnane is Professor in Electrical and Electronic Engineering in University College Cork (UCC). He received the B.E. degree in electrical engineering from UCC in 1984, and the D.Phil. degree from the University of Oxford, U.K., in 1989. He was appointed lecturer in VLSI Design at the School of Electronic Engineering Science, University of Wales, Bangor, in 1989. In 1992 he was awarded a Post Doctoral Marie Curie Fellowship from the European Union to investigate Design for Test of VLSI arrays at IRISA University of Rennes. In 1993 he was appointed as Lecturer in Digital Signal Processing in the Department of Electrical and Electronic Engineering at UCC, as Senior Lecturer in 1999 and Professor in 2014. He was vice head of the School of Engineering, UCC, from 2010 to 2013. He was Dean of Graduate Studies for UCC from 2013 to 2016. This research has focused on Neonatel EEG signal analysis and processing.