Paper Nr: |
7 |
Title: |
Application of the Technique of Magnetic Resonance Voxel-based Morphometry in Patients with Multiple Sclerosis before and after using High-dose Immunosuppressive Therapy with Autologous Hematopoietic Stem Cell Transplantation: Preliminary Results |
Authors: |
E. A. Gorbunova, G. N. Bisaga, A. G. Trufanov, M. P. Topuzova, A. V. Fokin, A. G. Levchuk, A. A. Medenikov, E. D. Vyshedkevich, T. A. Bukkieva, A. Yu. Efimtsev and I. A. Mashchenko |
Abstract: |
Correlation analysis of magnetic resonance voxel-based morphometric parameters of patients with multiple
sclerosis before and after high-dose immunosuppressive therapy with transplantation of autologous
hematopoietic stem cells (HDIT + AHSCT). The use of MR-morphometry methods makes it possible to
quantitatively and objectively changes of the volume and size of the structures of the brain and cerebellum in
patients with MS. We observed 10 patients with MS (3 men, 7 women) who underwent HDIT + AHSCT, and
MRI studies were performed before and after transplantation. After postprocessing of MRI data and statistic
analyses of morphometry parameters some changes were accrued: some patients showed negative dynamics
in white and grey mater volumes and decrease of the absolute volume of the thalamus. Also, study showed
positive dynamics in reducing the number of new MS lesions. These results can be associated with the result
of treatment, with a local decrease in edema and inflammation. Study showed the need for dynamic MR
control of the grey and white matter of the brain and subcortical structures with the help of MR morphometry. |
Download |
Paper Nr: |
9 |
Title: |
Functional Connectivity Assessment in Patients with Chronic-type Tension Headaches after Applying Osteopathic Correction |
Authors: |
A. V. Fokin, M. L. Pospelova, G. E. Trufanov, A. A. Medenikov, E. D. Vyshedkevich, I. A. Mashchenko, T. A. Bukkieva, D. S. Chegina, E. A. Gorbunova, T. M. Alekseeva and A. S. Lepekhina |
Abstract: |
Clinical and neuroimaging comparison of the dynamics of changes in the pain connectome against the background of osteopathic correction in patients with chronic tension-type headaches. We examined 24 patients with chronic tension type headaches, aged 24 to 43 years. Patients underwent resting-state functional MRI before and after first osteopathic manipulation. Complaints were evaluated and patients were surveyed to assess the intensity of headache and its impact on different areas of life, quality of life, situational and personal anxiety before and after therapy. Changes in the functional connectivity of the in patients with tension headaches after osteopathic manipulation were found to correlate with a positive clinical picture. Changes in the functional connections of the medial prefrontal cortex with other areas of the brain were detected in patients with chronic tension-type headaches when using a single osteopathic correction. There was an improvement in the condition of patients both in the subjective assessment of complaints and in the objective assessment of their condition on scales. The use of methods for statistical analysis of neuroimaging data, in particular resting-state functiontional MRI, made it possible to see the differences objectively by mapping different colors using color scales, which greatly simplifies the entire analytical process. Clinical and neuroimaging comparison of the dynamics of changes in the pain connectome against the background of osteopathic correction in patients with chronic tension-type headaches provides potentially new approaches to the diagnosis and treatment of pain syndrome. |
Download |